Methods for iPS cell generation for basic research and clinical applications

  title={Methods for iPS cell generation for basic research and clinical applications},
  author={Yuji Mochiduki and Keisuke Okita},
  journal={Biotechnology Journal},
The induction of pluripotency can be achieved by forced expression of defined factors in somatic cells. The established cells, termed induced pluripotent stem (iPS) cells, have pluripotency and an infinite capacity for self‐renewal in common with embryonic stem (ES) cells. Patient‐specific iPS cells could be a useful source for drug discovery and cell transplantation therapies; however, the original method for iPS cell generation had several issues that were obstacles to their clinical… 

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