Methods for generation of genetically modified fibroblasts for immunotherapy of cancer.

Abstract

Considerable evidence has accumulated indicating that cultured human or rodent tumor cells can be successfully transduced with cytokine genes and selected in the appropriate antibiotic-containing culture media. The selected transductants are generally able to secrete the cytokine coded for by the transduced gene, and in many cases, substantial levels (e.g… (More)
DOI: 10.1385/0-89603-484-4:349

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