Methods for Synthesizing Findings on Moderation Effects Across Multiple Randomized Trials

  title={Methods for Synthesizing Findings on Moderation Effects Across Multiple Randomized Trials},
  author={C Hendricks Brown and Zili Sloboda and Fabrizio Faggiano and Brent Teasdale and Ferdinand Keller and Gregor Burkhart and Federica Daniela Vigna-Taglianti and George W Howe and Katherine E. Masyn and Wei Wang and Bengt O. Muth{\'e}n and Peggy C. Stephens and Scott F. Grey and Tatiana Perrino},
  journal={Prevention Science},
This paper presents new methods for synthesizing results from subgroup and moderation analyses across different randomized trials. We demonstrate that such a synthesis generally results in additional power to detect significant moderation findings above what one would find in a single trial. Three general methods for conducting synthesis analyses are discussed, with two methods, integrative data analysis and parallel analyses, sharing a large advantage over traditional methods available in meta… CONTINUE READING
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