Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation.

@article{Takahashi2018MethodsFG,
  title={Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation.},
  author={Yoshinobu Takahashi and Takanori Takebe and Hideki Taniguchi},
  journal={Current protocols in stem cell biology},
  year={2018},
  volume={45 1},
  pages={
          e49
        }
}
Despite the promise of emerging organoid-based approaches, building additional complexity, such as the vascular network, remains a major challenge toward regenerative therapy. Recently, we developed a complex organoid engineering method by "self-condensation," wherein mesenchymal cell-dependent contraction enables large-scale condensation from heterotypic multiple progenitors. Here, we describe the adaptation of this protocol for generating three-dimensional (3D) pancreatic condensates from… CONTINUE READING
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