Methods development in multimodal chromatography with mobile phase modifiers using the steric mass action model.

@article{Karkov2013MethodsDI,
  title={Methods development in multimodal chromatography with mobile phase modifiers using the steric mass action model.},
  author={Hanne Sophie Karkov and Lars Sejergaard and Steven M. Cramer},
  journal={Journal of chromatography. A},
  year={2013},
  volume={1318},
  pages={149-55}
}
The ability to predict downstream protein purification processes is of great value in the biopharmaceutical industry; saving time, cost and resources. While many complex models exist, the appropriate use of simple models can be a useful tool for rapidly designing and optimizing processes as well as for risk analysis and establishing parameter ranges. In this study, the steric mass action isotherm is success-fully employed to predict the chromatographic behavior of a multimodal anionic Capto… CONTINUE READING

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