Corpus ID: 90586648

Methods and compositions for increasing the enzyme activity in Cns

@inproceedings{2014MethodsAC,
  title={Methods and compositions for increasing the enzyme activity in Cns},
  author={ウィリアム・エム・パードリッジ and ルーベン・ジェイ・ボアド},
  year={2014}
}
Herein provide methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). Bifunctional fusion antibodies herein, antibodies to endogenous the blood-brain barrier (BBB) ​​receptor, and comprises an enzyme which is deficient in mucopolysaccharidosis type III (MPS-III). Fusion antibodies herein, N- sulfonium glucosamine sulfonium hydrolase (SGSH), α-N- acetylglucosaminidase (NAGLU), heparin -α- glucosaminide N- acetyltransferase (HGSNAT… Expand