Methods and Statistics for Combining Motif Match Scores

  title={Methods and Statistics for Combining Motif Match Scores},
  author={Timothy L. Bailey and Michael Gribskov},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={5 2},
Position-specific scoring matrices are useful for representing and searching for protein sequence motifs. A sequence family can often be described by a group of one or more motifs, and an effective search must combine the scores for matching a sequence to each of the motifs in the group. We describe three methods for combining match scores and estimating the statistical significance of the combined scores and evaluate the search quality (classification accuracy) and the accuracy of the estimate… CONTINUE READING
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