Methods and Protocols for Developing Prion Vaccines.

  title={Methods and Protocols for Developing Prion Vaccines.},
  author={Kristen Marciniuk and Ryan Taschuk and Scott Napper},
  journal={Methods in molecular biology},
Prion diseases denote a distinct form of infectivity that is based in the misfolding of a self-protein (PrP(C)) into a pathological, infectious conformation (PrP(Sc)). Efforts to develop vaccines for prion diseases have been complicated by the potential dangers that are associated with induction of immune responses against a self-protein. As a consequence, there is considerable appeal for vaccines that specifically target the misfolded prion conformation. Such conformation-specific… CONTINUE READING

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