Methods, statistical features, and baseline results of a standardized, multicentered ophthalmologic surgical trial: the Silicone Study.

@article{Azen1991MethodsSF,
  title={Methods, statistical features, and baseline results of a standardized, multicentered ophthalmologic surgical trial: the Silicone Study.},
  author={Stanley Paul Azen and D. C. Boone and William Barlow and Brooks W. McCuen and A F Walonker and M M Anderson and J. S. Lean and Richard L. Mowery and Stephen J Ryan and W. Stern},
  journal={Controlled clinical trials},
  year={1991},
  volume={12 3},
  pages={438-55}
}
This article describes the trial design and baseline results for the Silicone Study, a multicenter, randomized surgical trial designed to compare the effectiveness of silicone fluid versus long-acting gas in the treatment of proliferative vitreoretinopathy (PVR). Design features include (1) standardization of the surgical protocol to reduce intersurgeon variability, (2) formulation of a PVR clinical classification system relevant to modern vitreoretinal surgery, and (3) creation of a… CONTINUE READING