Methodology for measuring in vitro/ex vivo cardiac energy metabolism.

  title={Methodology for measuring in vitro/ex vivo cardiac energy metabolism.},
  author={Rick L. Barr and Gary D Lopaschuk},
  journal={Journal of pharmacological and toxicological methods},
  volume={43 2},
The high energy demands of the heart are met primarily by the metabolism of fatty acids and carbohydrates. These energy substrates are efficiently and rapidly metabolized in order to produce the high levels of adenosine triphosphate (ATP) necessary to sustain both contractile activity and other cellular functions. Alterations in energy metabolism contribute to abnormal heart function in many cardiac diseases. As a result, a number of techniques have been developed to directly measure energy… CONTINUE READING

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