Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption.

@article{Badhan2009MethodologyFD,
  title={Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption.},
  author={Raj K S Badhan and Jeffrey Penny and Aleksandra Galetin and James Brian Houston},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 6},
  pages={
          2180-97
        }
}
The small intestine poses a major barrier to the efficient absorption of orally administered therapeutics. Intestinal epithelial cells are an extremely important site for extrahepatic clearance, primarily due to prominent P-glycoprotein-mediated active efflux and the presence of cytochrome P450s. We describe a physiologically based pharmacokinetic model which incorporates geometric variations, pH alterations and descriptions of the abundance and distribution of cytochrome 3A and P-glycoprotein… CONTINUE READING
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