Methodology and accuracy of estimation of quantitative trait loci parameters in a half-sib design using maximum likelihood.

@article{Mackinnon1995MethodologyAA,
  title={Methodology and accuracy of estimation of quantitative trait loci parameters in a half-sib design using maximum likelihood.},
  author={Margaret J Mackinnon and Joel I Weller},
  journal={Genetics},
  year={1995},
  volume={141 2},
  pages={755-70}
}
Maximum likelihood methods were developed for estimation of the six parameters relating to a marker-linked quantitative trait locus (QTL) segregating in a half-sib design, namely the QTL additive effect, the QTL dominance effect, the population mean, recombination between the marker and the QTL, the population frequency of the QTL alleles, and the within-family residual variance. The method was tested on simulated stochastic data with various family structures under two genetic models. A method… CONTINUE READING

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