Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research

@article{Bourdonnec2013MethodologiesTA,
  title={Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research},
  author={C{\'e}line Passeleu-Le Bourdonnec and Pierre-Alain Carrupt and Jean Michel G. Scherrmann and Sophie Martel},
  journal={Pharmaceutical Research},
  year={2013},
  volume={30},
  pages={2729-2756}
}
The drug discovery process for drugs that target the central nervous system suffers from a very high rate of failure due to the presence of the blood–brain barrier, which limits the entry of xenobiotics into the brain. To minimise drug failure at different stages of the drug development process, new methodologies have been developed to understand the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of drug candidates at early stages of drug development. Additionally… CONTINUE READING
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In silico models to predict brain uptake

  • AbrahamMH, A Hersey
  • Comprehensive Medicinal chemistry II, Elsevier…
  • 2007
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