Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors.

@article{Bucher2016MethodologiesFS,
  title={Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors.},
  author={Tabitha Bucher and Elena Kartvelishvily and Ilana Kolodkin-Gal},
  journal={Journal of visualized experiments : JoVE},
  year={2016},
  volume={116}
}
This work assesses different methodologies to study the impact of small molecule biofilm inhibitors, such as D-amino acids, on the development and resilience of Bacillus subtilis biofilms. First, methods are presented that select for small molecule inhibitors with biofilm-specific targets in order to separate the effect of the small molecule inhibitors on planktonic growth from their effect on biofilm formation. Next, we focus on how inoculation conditions affect the sensitivity of… CONTINUE READING
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