Methodologies for Measuring Carcinogen Adducts in Humans 1

  title={Methodologies for Measuring Carcinogen Adducts in Humans 1},
  author={Paul Timothy Strickland and Michael N Routledge and Anthony Dipple},
Introduction Interest in carcinogen adducts arose from studies carried out in the 1 960s and early 1970s that showed a common factor among genotoxic chemical carcinogens (e.g., nitrosamines, aromatic amines, azo-dyes, PAH,2 various natural products and alkylating agents) was that, despite their structural diversity, they were either intrinsically reactive toward cellular macromolecules on they were metabolically converted to derivatives with such reactivity (1 -3). Thereafter, carcinogen… CONTINUE READING

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Publications referenced by this paper.

Dedine ofthe hemoglobin adduct

M. Maclure, M. S. Bryant, P. L. Skipper, S. R. Tannenhaum
  • carcinogens. Cancer Res.,
  • 1992

correlation with adduct levels in lung

M. P. Chiarelli, Lay, Jr.
  • Carcinogenesis (Lond.),
  • 1992