Methodological shortcomings predicted lower harm estimates in one of two sets of studies of clinical interventions.

@article{Chou2007MethodologicalSP,
  title={Methodological shortcomings predicted lower harm estimates in one of two sets of studies of clinical interventions.},
  author={Roger Chou and Ruibo Fu and Susan Carson and Somnath Saha and Mark Helfand},
  journal={Journal of clinical epidemiology},
  year={2007},
  volume={60 1},
  pages={18-28}
}
OBJECTIVES High quality harms data are necessary to appropriately assess the balance between benefits and harms of interventions. Little is known, however, about whether perceived methodological shortcomings are associated with lower estimates of harms. STUDY DESIGN AND SETTING Studies reporting harms associated with carotid endarterectomy (CEA) and rofecoxib were identified using published systematic reviews. A standardized abstraction form, including eight predefined criteria for assessing… CONTINUE READING

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