Methodological issues in studying rates and predictors of migraine progression and remission.

  title={Methodological issues in studying rates and predictors of migraine progression and remission.},
  author={Richard B. Lipton and Donald B. Penzien and Dana P Turner and Todd A Smitherman and Timothy T. Houle},
  volume={53 6},
BACKGROUND The progression and remission of migraine and the risk factors that determine the course of illness have been intensively studied for the past decade. METHODS In this fourth paper in a series of methodological articles, we summarize crucial issues that influence studies of migraine clinical course, and suggest directions and opportunities for future research. RESULTS Defining chronic migraine (CM) based on 15 or more headache days per month is problematic because headache… CONTINUE READING
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