Methodological challenges in mendelian randomization.

  title={Methodological challenges in mendelian randomization.},
  author={Tyler J. VanderWeele and Eric J Tchetgen Tchetgen and Marilyn Cornelis and Peter Kraft},
  volume={25 3},
We give critical attention to the assumptions underlying Mendelian randomization analysis and their biological plausibility. Several scenarios violating the Mendelian randomization assumptions are described, including settings with inadequate phenotype definition, the setting of time-varying exposures, the presence of gene-environment interaction, the existence of measurement error, the possibility of reverse causation, and the presence of linkage disequilibrium. Data analysis examples are… CONTINUE READING