Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels.

@article{Andersson2007MethodologicalAO,
  title={Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels.},
  author={Lena M C Andersson and P. -{\aa}. Lundberg and Lars Barreg{\aa}rd},
  journal={Journal of applied toxicology : JAT},
  year={2007},
  volume={27 1},
  pages={60-6}
}
The Clara cell protein CC16, secreted from Clara cells in the lung, is discussed as a potential biomarker for toxic effects on the airways. An increased concentration of CC16 in serum may be caused by increased permeability of the lungs, caused by high levels of air pollution. Since CC16 is eliminated by renal excretion, it may be possible to use urine instead of serum samples. Few studies have been conducted on urinary CC16 (U-CC16), however. The aim was to investigate the optimal way of… CONTINUE READING
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