Methodological aspects for metabolome visualization and characterization: a metabolomic evaluation of the 24 h evolution of human urine after cocoa powder consumption.

@article{LlorachAsuncin2010MethodologicalAF,
  title={Methodological aspects for metabolome visualization and characterization: a metabolomic evaluation of the 24 h evolution of human urine after cocoa powder consumption.},
  author={R Llorach-Asunci{\'o}n and Olga J{\'a}uregui and Mireia Urpi-Sard{\`a} and Cristina Andres-Lacueva},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2010},
  volume={51 2},
  pages={373-81}
}
The LC-MS based metabolomics studies are characterized by the capacity to produce a large and complex dataset being mandatory to use the appropriate tools to recover and to interpret as maximum information as possible. In this context, a combined partial least square discriminat analysis (PLS-DA) and two-way hierarchical clustering (two-way HCA) using Bonferroni correction as filter is proposed to improve analysis in human urinary metabolome modifications in a nutritional intervention context… CONTINUE READING

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