Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer.

@article{Spindler2017MethodologicalBA,
  title={Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer.},
  author={K G Spindler},
  journal={Acta oncologica},
  year={2017},
  volume={56 1},
  pages={7-16}
}
BACKGROUND Circulating DNA can be used to measure the total cell-free DNA (cfDNA) and for detection and quantification of tumor-specific genetic alterations in the peripheral blood, and the broad clinical potential of circulating DNA has attracted increasing focus over the past decade. Concentrations of circulating DNA are high in metastatic colorectal cancer (CRC), and the total levels of cfDNA have been reported to hold strong prognostic value. Colorectal tumors are characterized by a high… CONTINUE READING