Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB

@inproceedings{Garton2018MethodTG,
  title={Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB},
  author={Michael Garton and Satra Nim and Tracy A. Stone and Kyle Ethan Wang and Charles M. Deber and Philip M. Kim},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018}
}
Biologics are a rapidly growing class of therapeutics with many advantages over traditional small molecule drugs. A major obstacle to their development is that proteins and peptides are easily destroyed by proteases and, thus, typically have prohibitively short half-lives in human gut, plasma, and cells. One of the most effective ways to prevent degradation is to engineer analogs from dextrorotary (D)-amino acids, with up to 105-fold improvements in potency reported. We here propose a general… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

A potent Dprotein antagonist of VEGFA is nonimmunogenic , metabolically stable , and longercirculating in vivo

M Uppalapati
  • ACS Chem Biol
  • 2016

Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking

SN Roed
  • J Biol Chem
  • 2015
VIEW 2 EXCERPTS

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