Method to Estimate the Rate and Extent of Intestinal Absorption in Conscious Rats Using an Absorption Probe and Portal Blood Sampling

@article{Hoffman1995MethodTE,
  title={Method to Estimate the Rate and Extent of Intestinal Absorption in Conscious Rats Using an Absorption Probe and Portal Blood Sampling},
  author={Daniel J. Hoffman and Terese Seifert and Anthony Borre and Hugh N. Nellans},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={889-894}
}
Purpose. A variety of methods exist which determine the rate and extent of intestinal absorption. The method described here employs an internal absorption reference probe and portal blood sampling in unanesthetized rat. Methods. Theophylline and tritiated water were selected as absorption reference probes since they are quantitatively absorbed in conscious rat. The fraction of an intestinal dose which reaches portal blood was determined from the resulting portal-systemic blood concentration… CONTINUE READING

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