Method of creating a nanopore-terminated probe for single-molecule enantiomer discrimination.

  title={Method of creating a nanopore-terminated probe for single-molecule enantiomer discrimination.},
  author={Changlu Gao and Shu chun Ding and Qiulin Tan and Li-Qun Gu},
  journal={Analytical chemistry},
  volume={81 1},
Nanopores are increasingly utilized as tools for single-molecule detection in biotechnology. Many nanopores are fabricated through procedures that require special materials, expensive facilities and experienced operators, which limit their usefulness on a wider scale. We have developed a simple method of fabricating a robust, low-noise nanopore by externally penetrating a nanocavity enclosed in the terminal of a capillary pipet. The nanocavity was shown to have a pore size on the scale of a… CONTINUE READING

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