Method of administration determines the effect of naloxone on pain.

@article{Levine1986MethodOA,
  title={Method of administration determines the effect of naloxone on pain.},
  author={Jon D Levine and Newton C. Gordon},
  journal={Brain research},
  year={1986},
  volume={365 2},
  pages={377-8}
}
The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to administer different doses of naloxone. We report that use of machine infusion of naloxone exclusively produces analgesia. The implications of this finding to the mechanism of… CONTINUE READING

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