Method development for HILIC assays.

@article{Dejaegher2008MethodDF,
  title={Method development for HILIC assays.},
  author={Bieke Dejaegher and Debby Mangelings and Yvan Vander Heyden},
  journal={Journal of separation science},
  year={2008},
  volume={31 9},
  pages={
          1438-48
        }
}

• Bieke Dejaegher, Debby Mangelings, Yvan Vander Heyden
• Published 2008 in Journal of separation science
• DOI:10.1002/jssc.200700680

In this review, method development for hydrophilic interaction LC (HILIC) is highlighted. HILIC is a chromatographic technique that uses aqueous-organic solvent mobile phases with a high organic-solvent fraction, and a hydrophilic stationary phase. It is mainly applied for the separation of polar and hydrophilic compounds. Method development, in general, can be done uni- or multivariately. In the univariate approach, the factors that are expected to potentially affect the separation of the… CONTINUE READING

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