Method development for HILIC assays.

  title={Method development for HILIC assays.},
  author={Bieke Dejaegher and Debby Mangelings and Yvan Vander Heyden},
  journal={Journal of separation science},
  volume={31 9},
In this review, method development for hydrophilic interaction LC (HILIC) is highlighted. HILIC is a chromatographic technique that uses aqueous-organic solvent mobile phases with a high organic-solvent fraction, and a hydrophilic stationary phase. It is mainly applied for the separation of polar and hydrophilic compounds. Method development, in general, can be done uni- or multivariately. In the univariate approach, the factors that are expected to potentially affect the separation of the… CONTINUE READING
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