Methoctramine induces nonspecific airway hyperresponsiveness in vivo.

@article{Howell1994MethoctramineIN,
  title={Methoctramine induces nonspecific airway hyperresponsiveness in vivo.},
  author={R. Howell and M. Kovalsky and K. Laemont},
  journal={European journal of pharmacology},
  year={1994},
  volume={265 1-2},
  pages={
          67-75
        }
}
  • R. Howell, M. Kovalsky, K. Laemont
  • Published 1994
  • Chemistry, Medicine
  • European journal of pharmacology
  • We investigated the effects of subtype-selective muscarinic receptor antagonists upon aerosol antigen-induced bronchoconstriction in anesthetized guinea pigs. Neither pirenzepine (muscarinic M1 receptor-selective), 4-methylpiperidine methiodide (4-DAMP, muscarinic M3 receptor-selective), [N-iminomethyl-N'-[(2-hydroxy-2-phenyl-2-cyclohexyl)-ethyl] piperazine HCl (DAC-5945, muscarinic M3 receptor-selective), ipratropium or atropine inhibited bronchoconstriction, but methoctramine (muscarinic M2… CONTINUE READING
    2 Citations

    References

    SHOWING 1-10 OF 32 REFERENCES
    Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.
    • 5
    Evidence for prejunctional M2 muscarinic receptors in pulmonary cholinergic nerves in the rat
    • 57
    Functional characterization of muscarinic receptors in murine airways
    • 39