Methocarbamol bei akuten Rückenschmerzen

  title={Methocarbamol bei akuten R{\"u}ckenschmerzen},
  author={Oliver M. D. Emrich and K. A. Milachowski and Martin Strohmeier},
  journal={MMW - Fortschritte der Medizin},
ZusammenfassungHintergrund:Muskelrelaxantien sind ein wichtiger Teil der Behandlungsstrategie bei Rückenschmerzen (LBP, Low Back Pain), einem der häufigsten gesundheitlichen Probleme in Industrienationen. Für diese Indikation hat die Europäische Arzneimittelbehörde (EMA) jüngst Anwendungsausschlüsse für Muskelrelaxantien, aber auch Antiphlogistika und Analgetika, und sogar Marktrücknahmen (Tetrazepam) angeordnet. Als einzig explizit zugelassenes Muskelrelaxans ist Methocarbamol verblieben. Die… Expand
6 Citations
Wirksamkeit und Verträglichkeit von Methocarbamol bei muskulär bedingten subakuten Kreuz-/Rückenschmerzen
In einer nichtinterventionellen Kohortenstudie erfolgte unter Verwendung anonymisierter Routinedaten des DGS-PraxisRegister Schmerz die retrospektive Evaluation of Patienten mit therapieschwierigen Kreuz-/Rückenschmerzen, known to be difficult to treat and requires more specific muscle-oriented treatments. Expand
The Safety and Efficacy of Methocarbamol as a Muscle Relaxant with Analgesic Action: Analysis of Current Data
Methocarbamol has proven to be an effective and safe drug for use as a supplement to exercise regimen, physiotherapy and other activities to ease the discomfort associated with acute musculoskeletal disorders. Expand
Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis
Considerable uncertainty exists about the clinical efficacy and safety of muscle relaxants and very low and low certainty evidence shows that non-benzodiazepine antispasmodics might provide small but not clinically important reductions in pain intensity at or before two weeks and might increase the risk of an adverse event in acute low back pain, respectively. Expand
Methadone-based Multimodal Analgesia Provides the Best-in-class Acute Surgical Pain Control and Functional Outcomes With Lower Opioid Use Following Major Posterior Fusion Surgery in Adolescents With Idiopathic Scoliosis
Methadone-based multimodal analgesia resulted in significantly lower LOS compared with the conventional regimen, and provided improved pain control, reduced total opioid consumption, and early bowel movementCompared with the control group. Expand
Methocarbamol blocks muscular Nav1.4 channels and decreases isometric force of mouse muscles
The muscle relaxant methocarbamol is widely used for the treatment of muscle spasms and pain syndromes and its influence on neuromuscular transmission, on isometric muscle force, and on voltage‐gated Na+ channels is studied. Expand
Pain Management for Chronic Musculoskeletal Disorders
  • Alexander J. Kim, Tennison L. Malcolm, Ehren R. Nelson
  • Medicine
  • Principles of Orthopedic Practice for Primary Care Providers
  • 2021


Neurobiologische Grundlagen von Muskelschmerz
The peripheral mechanism underlying the tenderness and pain during movement of a damaged muscle is the sensitization of muscle nociceptors, which is associated with an overexcitability of neurones (central sensitization) and contribute to hyperalgesia of patients. Expand
Methocarbamol (robaxin) in orthopedic conditions; preliminary report of one hundred cases.
  • H. F. Forsyth
  • Medicine
  • Journal of the American Medical Association
  • 1958
Methocarbamol was particularly useful in such procedures as reducing dislocated shoulders without anesthesia and manipulating spastic feet, and in recovering patients recovering from orthopedic surgery. Expand
A Clinical Study of 46 Males With Low-Back Disorders Treated with Methocarbamol
T he double-blind, randomized control trial (in which neither the patient nor the observer knows the treatments, each of which is administered randomly) is considered the gold standard of designs toExpand
Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials
P acetamol is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis, and these results support the reconsideration of recommendations to use paracetamol for patients with low backPain and osteOarthritis of the hip or knee in clinical practice guidelines. Expand
Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials
The results are discussed in terms of depressant actions of the drugs on α‐motorneurones, effects of the Drugs at higher centres concerned with motor function, and the lack of evidence that spinal interneurones represent a specific site of action for centrally acting skeletal muscle relaxants. Expand
Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.
The present study clearly differentiated the behavioral and subjective profiles of diphenhydramine, lorazepam and methocarbamol, consistent with its recognized low abuse liability. Expand
Some studies on peripheral actions of mephenesin, methocarbamol and diazepam
Mephenesin and methocarbamol caused a prolongation of the mean refractory period of directly or indirectly stimulated skeletal muscle and their mode of action in reducing muscle spasm is discussed. Expand
Evaluation of the abuse potential of methocarbamol.
Methocarbamol, at doses well above those used therapeutically, has some potential to be abused by persons with histories of sedative/hypnotic abuse; however, this potential for abuse is probably decreased by the accompanying side effects at high doses and is probably less than that of lorazepam. Expand
50 Years Ago in CORR: A Clinical Study of 46 Males With Low-Back Disorders Treated with Methocarbamol Andres Grisolia MD and J.E.M. Thomson CORR 1959;13:299–304
  • R. Brand
  • Medicine
  • Clinical orthopaedics and related research
  • 2009
The double-blind, randomized control trial (in which neither the patient nor the observer knows the treatments, each of which is administered randomly) is considered the gold standard of designs toExpand
Non-specific low back pain
Two treatment strategies are currently used, a stepped approach beginning with more simple care that is progressed if the patient does not respond, and the use of simple risk prediction methods to individualise the amount and type of care provided. Expand