Methocarbamol (robaxin) in orthopedic conditions; preliminary report of one hundred cases.

@article{Forsyth1958MethocarbamolI,
  title={Methocarbamol (robaxin) in orthopedic conditions; preliminary report of one hundred cases.},
  author={H. F. Forsyth},
  journal={Journal of the American Medical Association},
  year={1958},
  volume={167 2},
  pages={
          163-8
        }
}
  • H. F. Forsyth
  • Published 1958
  • Medicine
  • Journal of the American Medical Association
The ability of methocarbamol to relax spastic muscles was noted incidentally to other studies, but was found to merit special investigation. The effects here reported were obtained in 58 patients with acute orthopedic conditions (especially herniated lumbar and cervical disks) causing painful muscular spasms, 7 patients with chronic conditions, and 18 patients recovering from orthopedic surgery. The average oral dose of methocarbamol was 6 Gm. per day in divided doses, using 500-mg. scored… Expand
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Plasma levels of mephenesin, mephenesin carbamate, guaiacol glyceryl ether, and methocarbamol (AHR-85) after oral and intravenous administration in the dog.
TLDR
The absence of free guaiacol glyceryl ether in the plasma after oral AHR-85 administration indicates that the intact molecule of this carbamate is the active agent in the dog. Expand
A PHARMACOLOGIC COMPARISON OF METHOCARBAMOL (AHR-85), THE MONOCARBAMATE OF 3-(o-METHOXYPHENOXY)-1,2-PROPANEDIOL WITH CHEMICALLY RELATED INTERNEURONAL DEPRESSANT DRUGS
Measurement of the oral effectiveness of mephenesin, mephenesin carbamate, guiacol glyceryl ether (GGE) and the monocarbamate of GGE (AHR-85) in the rat by challenging doses of strychnine afterExpand