Methionine synthase. a possible prime site of the ethanolic lesion in liver.

@article{Barak2002MethionineSA,
  title={Methionine synthase. a possible prime site of the ethanolic lesion in liver.},
  author={Anthony J. Barak and Harriet C. Beckenhauer and Dean J. Tuma},
  journal={Alcohol},
  year={2002},
  volume={26 2},
  pages={
          65-7
        }
}
  • Anthony J. Barak, Harriet C. Beckenhauer, Dean J. Tuma
  • Published in Alcohol 2002
  • Psychology, Medicine
  • Among the most important pathways for liver integrity in the body are the two that synthesize methionine and S-adenosylmethionine (SAM) through methylation of homocysteine. Results of studies in this laboratory have demonstrated ethanolic inhibition of one of these pathways catalyzed by methionine synthetase. It has been shown elsewhere that alcohol per se does not inhibit the enzyme, but that the metabolite of ethanol, acetaldehyde, is responsible through the formation of an inhibiting… CONTINUE READING

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