Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism.

@article{Salomon2001MethionineSA,
  title={Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism.},
  author={O Salomon and Nurit Rosenberg and Ariella Zivelin and David M. Steinberg and Nurit Kornbrot and Rima Dardik and Aida Inbal and Uri Seligsohn},
  journal={The hematology journal : the official journal of the European Haematology Association},
  year={2001},
  volume={2 1},
  pages={
          38-41
        }
}
Hyperhomocysteinemia is a defined risk factor for venous thromboembolism (VTE). Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE. Indeed, homozygous MTHFR C677T was… CONTINUE READING

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References

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SHOWING 1-10 OF 26 REFERENCES

E€ect of methyelenetetrahydrofolate reductase 677C-T, 1298A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients

N Akar, E Akar, +3 authors C. Sukru
  • Thrombosis Research
  • 2000

High levels of factor VIII and venous thrombosis.

  • Thrombosis and haemostasis
  • 2000
VIEW 1 EXCERPT