Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.

@article{Tarrago2012MethionineSR,
  title={Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.},
  author={Lionel Tarrago and Alaattin Kaya and Eranthie Weerapana and Stefano M. Marino and Vadim N. Gladyshev},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 29},
  pages={24448-59}
}
Reduction of methionine sulfoxide (MetO) residues in proteins is catalyzed by methionine sulfoxide reductases A (MSRA) and B (MSRB), which act in a stereospecific manner. Catalytic properties of these enzymes were previously established mostly using low molecular weight MetO-containing compounds, whereas little is known about the catalysis of MetO reduction… CONTINUE READING