Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.

@article{Kantorow2004MethionineSR,
  title={Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.},
  author={Marc Kantorow and John R Hawse and Tracy L Cowell and Sonia Benhamed and Gresin O. Pizarro and V. S. N. Reddy and J Fielding Hejtmancik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 26},
  pages={9654-9}
}
Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which is related to oxidative stress damage. Oxidation of methionine to methionine sulfoxide is a major oxidative stress product that reaches levels as high as 60% in cataract while being essentially absent from clear lenses. Methionine oxidation results in loss of protein function that can be reversed through the action of methionine sulfoxide reductase A (MsrA), which is… CONTINUE READING

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