Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.

@article{Moskovitz2016MethionineSR,
  title={Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.},
  author={Jackob Moskovitz and Fang Du and Connor F. Bowman and Shirley ShiDu Yan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2016},
  volume={310 6},
  pages={E388-93}
}
Accumulation of oxidized proteins, and especially β-amyloid (Aβ), is thought to be one of the common causes of Alzheimer's disease (AD). The current studies determine the effect of an in vivo methionine sulfoxidation of Aβ through ablation of the methionine sulfoxide reductase A (MsrA) in a mouse model of AD, a mouse that overexpresses amyloid precursor protein (APP) and Aβ in neurons. Lack of MsrA fosters the formation of methionine sulfoxide in proteins, and thus its ablation in the AD-mouse… CONTINUE READING
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