Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress.

@article{Zhang2010MethionineSR,
  title={Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress.},
  author={Chi Zhang and Pingping Jia and Yuanyuan Jia and Herbert Weissbach and Keith A. Webster and Xupei Huang and Sharon L. Lemanski and Mohan P. Achary and Larry F. Lemanski},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={111 1},
  pages={
          94-103
        }
}
Methionine sulfoxide reductase A (MsrA), a member of the Msr gene family, can reduce methionine sulfoxide residues in proteins formed by oxidation of methionine by reactive oxygen species (ROS). Msr is an important protein repair system which can also function to scavenge ROS. Our studies have confirmed the expression of MsrA in mouse embryonic stem cells (ESCs) in culture conditions. A cytosol-located and mitochondria-enriched expression pattern has been observed in these cells. To confirm the… CONTINUE READING
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