Methionine restriction up-regulates the expression of the pi class of glutathione S-transferase partially via the extracellular signal-regulated kinase-activator protein-1 signaling pathway initiated by glutathione depletion.

@article{Tsai2010MethionineRU,
  title={Methionine restriction up-regulates the expression of the pi class of glutathione S-transferase partially via the extracellular signal-regulated kinase-activator protein-1 signaling pathway initiated by glutathione depletion.},
  author={Chia-Wen Tsai and Ai-Hsuan Lin and Tsung-Shing Andrew Wang and Kai-Li Liu and H P Chen and C D Lii},
  journal={Molecular nutrition & food research},
  year={2010},
  volume={54 6},
  pages={841-50}
}
Understanding the molecular events underlying gene regulation by amino acids has attracted increasing attention. Here, we explored whether the mechanism by which methionine restriction affects the expression of the pi class of glutathione S-transferase (GSTP) is related to oxidative stress initiated by glutathione (GSH) depletion. Rat primary hepatocytes were cultured in an L-15-based medium in the absence or presence of 200 muM L-buthionine sulfoximine (BSO) or in a methionine-restricted L-15… CONTINUE READING
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