Corpus ID: 22047491

Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.

@article{Najim2009MethionineRR,
  title={Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.},
  author={N. Najim and I. Podmore and A. McGown and E. Estlin},
  journal={Anticancer research},
  year={2009},
  volume={29 8},
  pages={
          3103-8
        }
}
BACKGROUND The aim of this study was to investigate the effects of methionine depletion with cytotoxic agents that are potentially influenced by depletion of methionine, and are known to have a role in CNS tumour treatments for children. MATERIALS AND METHODS Cytotoxicity studies and synergistic interactions were assayed by SRB assay. Glutathione levels were assayed by HPLC after derivatization with OPA. MGMT activity was determined by a restriction endonuclease inhibition assay. RESULTS… Expand
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References

SHOWING 1-7 OF 7 REFERENCES
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
Inhibition of glutathione efflux from isolated rat hepatocytes by methionine.