Methionine restriction inhibits colon carcinogenesis.

  title={Methionine restriction inhibits colon carcinogenesis.},
  author={Despina Komninou and Yvonne Leutzinger and B. Somasekhara Reddy and John P Richie},
  journal={Nutrition and cancer},
  volume={54 2},
Previously, we demonstrated that life-long methionine restriction (MR) in rats increases life span and inhibits aging-related disease processes. The present study examines the effects of MR on the formation of preneoplastic aberrant crypt foci (ACF) in the colon of azoxymethane (AOM)-treated rats. Six-week-old male F344 rats were placed on essential amino acid-defined diets containing either 0.86% Met (control diet) or 0.17% Met (MR diet) and 1 wk later were given AOM (15 mg/kg/wk, s.c.) for 2… CONTINUE READING


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