Methionine restriction increases blood glutathione and longevity in F344 rats

@article{Richie1994MethionineRI,
  title={Methionine restriction increases blood glutathione and longevity in F344 rats},
  author={J. Richie and Y. Leutzinger and Saudhamini Parthasarathy and Virginia Maixoy and N. Orentreich and J. A. Zimmerman},
  journal={The FASEB Journal},
  year={1994},
  volume={8},
  pages={1302 - 1307}
}
Little is known about the biochemical mechanisms responsible for the biological aging process. Our previous results and those of others suggest that one possible mechanism is based on the loss of glutathione (GSH), a multifunctional tripeptide present in high concentrations in nearly all living cells. The recent finding that life‐long dietary restriction of the GSH precursor methionine (Met) resulted in increased longevity in rats led us to hypothesize that adaptive changes in Met and GSH… Expand
Nutritional control of aging
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