Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities.

@article{Teh1987MethionineOI,
  title={Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities.},
  author={L C Teh and Liam J. Murphy and Noorjahan Laila Huq and A S Surus and Henry G. Friesen and Leslie Lazarus and Gwenneth E. Chapman},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 14},
  pages={6472-7}
}
The oxidation of the methionine residues of human growth hormone (hGH) and human chorionic somatomammotropin (hCS) to methionine sulfoxide by hydrogen peroxide has been studied. The kinetics of oxidation of individual methionine residues has been measured by reverse-phase high pressure liquid chromatography tryptic peptide mapping. Met-170 is completely resistant to oxidation in both hormones. The other 3 methionine residues in hCS (Met-64, Met-96, and Met-179) have markedly different reaction… CONTINUE READING