Methionine metabolism in mammals. Adaptation to methionine excess.

  title={Methionine metabolism in mammals. Adaptation to methionine excess.},
  author={James D. Finkelstein and John J. Martin},
  journal={The Journal of biological chemistry},
  volume={261 4},
We conducted a systematic evaluation of the effects of increasing levels of dietary methionine on the metabolites and enzymes of methionine metabolism in rat liver. Significant decreases in hepatic concentrations of betaine and serine occurred when the dietary methionine was raised from 0.3 to 1.0%. We observed increased concentrations of S-adenosylhomocysteine in livers of rats fed 1.5% methionine and of S-adenosylmethionine and methionine only when the diet contained 3.0% methionine… CONTINUE READING
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