Methionine-mediated lethality in yeast cells at elevated temperature.

  title={Methionine-mediated lethality in yeast cells at elevated temperature.},
  author={Hieronim Jakubowski and Emanuel Goldman},
  journal={Journal of bacteriology},
  volume={175 17},
Saccharomyces cerevisiae cells grown at 30 degrees C in minimal medium containing methionine lose viability upon transfer to 45 degrees C, whereas cells grown in the absence of methionine survive. Cellular levels of two intermediates in the sulfate assimilation pathway, adenosine 5'-phosphosulfate (APS) and adenosine 5'-phosphosulfate 3'-phosphate, are increased by a posttranslational mechanism after sudden elevation of temperature in yeast cultures grown in the absence of methionine. Yeast… CONTINUE READING

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