Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.

  title={Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.},
  author={Eric O. Uthus and Holly M Brown-Borg},
  journal={Mechanisms of ageing and development},
  volume={127 5},
Long-lived Ames dwarf mice lack growth hormone, prolactin, and thyroid stimulating hormone. Additionally the dwarf mice have enzyme activities and levels that combat oxidative stress more efficiently than those of normal mice. We have shown that methionine metabolism in Ames mice is markedly different than in their wild type littermates. In our previous work we hypothesized that the flux of methionine to the transsulfuration pathway is enhanced in the dwarf mice. The current study was designed… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Brown-Borg / Mechanisms of Ageing and Development

  • H.M.E.O. Uthus
  • 2006
Highly Influential
5 Excerpts

Mitochondrial oxidant production and oxidative damage in Ames dwarf mice

  • H. M. Brown-Borg, W. T. Johnson, S. G. Razoczy, M. A. Romanick
  • J. Am. Aging Assoc
  • 2001
Highly Influential
12 Excerpts

Similar Papers

Loading similar papers…