Methionine dependence of tumor cells: programmed cell survival?

Abstract

A majority of tumor cell lines are considered to be "methionine-dependent" because of their inability to grow in culture when methionine is replaced by its precursor, homocysteine. We have previously shown that this phenotype is not due to the incapacity to synthesize methionine from homocysteine but rather to a deficiency in the "methionine salvage pathway… (More)

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