Methionine dependence in cancer cells — A review

@article{Hoffman1982MethionineDI,
  title={Methionine dependence in cancer cells — A review},
  author={Robert M Hoffman},
  journal={In Vitro},
  year={1982},
  volume={18},
  pages={421-428}
}
Methionine dependence is a defect found in many cancer cell lines that inhibits their growth in culture when methionine is replaced by its immediate precursor, homocysteine, in the culture medium. Normal cultured cells do not have this defect. This report lists the diverse and large number of animal and human cancer lines that are methionine-dependent, and critically reviews the cell biology and methionine biochemistry of the phenomenon. 

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Methionine dependence is a defect found in many cancer cell lines that inhibits their growth in culture when methionine is replaced by its immediate precursor , homocysteine , in the culture medium .
Methionine dependence is a defect found in many cancer cell lines that inhibits their growth in culture when methionine is replaced by its immediate precursor , homocysteine , in the culture medium .
Methionine dependence is a defect found in many cancer cell lines that inhibits their growth in culture when methionine is replaced by its immediate precursor , homocysteine , in the culture medium .
Methionine dependence is a defect found in many cancer cell lines that inhibits their growth in culture when methionine is replaced by its immediate precursor , homocysteine , in the culture medium .
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