Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice.

@article{Essien1993MethionineBN,
  title={Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice.},
  author={Francine B. Essien and Sharon L. Wannberg},
  journal={The Journal of nutrition},
  year={1993},
  volume={123 1},
  pages={27-34}
}
The Axd (axial defects) mutation, which causes open neural tube defects (NTD) in 25-30% of d 14 mouse embryos of heterozygous (Axd/+) matings and curly tails (CT) in 31%, can be useful in studying neurovertebral morphogenesis. Current interest focuses on the role of methionine in neurulation, because supplementation of dams with this essential amino acid (70 mg/kg body wt) has been shown to reduce by 41% the incidence of NTD among embryos of Axd/+ x Axd/+ crosses when administered on d 8 and 9… CONTINUE READING

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