Methionine Restriction Inhibits Colon Carcinogenesis

@article{Komninou2006MethionineRI,
  title={Methionine Restriction Inhibits Colon Carcinogenesis},
  author={Despina Komninou and Yvonne Leutzinger and Bandaru S. Reddy and John P. Richie Jr.},
  journal={Nutrition and Cancer},
  year={2006},
  volume={54},
  pages={202 - 208}
}
Previously, we demonstrated that life-long methionine restriction (MR) in rats increases life span and inhibits aging-related disease processes. [...] Key Method Six-week-old male F344 rats were placed on essential amino acid-defined diets containing either 0.86% Met (control diet) or 0.17% Met (MR diet) and 1 wk later were given AOM (15 mg/kg/wk, s.c.) for 2 consecutive wk. Ten weeks after the final AOM treatment, ACF formation was markedly reduced in rats fed the MR diet with ACF containing > or = 4 crypts…Expand
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TLDR
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These results suggest that adaptive changes occur in the metabolism of Met, cysteine, and/or GSH as a result of MR in young and adult rats, which lead to conservation of GSH levels in most extrahepatic tissues and increased GSH in erythrocytes by depleting liver GSH to a critical level. Expand
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