Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.

@article{Krasowski2001Methionine2I,
  title={Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.},
  author={Matthew D. Krasowski and Koichi Nishikawa and Natalia Vikentievna Nikolaeva and Albert Lin and Neil L. Harrison},
  journal={Neuropharmacology},
  year={2001},
  volume={41 8},
  pages={
          952-64
        }
}
gamma-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis techniques have identified amino acid residues that are important for the positive modulation of GABA(A) receptors by general anesthetics. In the present study, we investigate the role of an amino acid residue in transmembrane (TM) domain 3 of the GABA(A) receptor beta(2) subunit for modulation by the general anesthetic 2,6-diisopropylphenol… CONTINUE READING

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