Methimazole pharmacology in the rat: studies using a newly developed radioimmunoassay for methimazole.

@article{Cooper1984MethimazolePI,
  title={Methimazole pharmacology in the rat: studies using a newly developed radioimmunoassay for methimazole.},
  author={D. Cooper and J. David Kieffer and V C Saxe and H Mover and Farahe Maloof and Eli Chester Ridgway},
  journal={Endocrinology},
  year={1984},
  volume={114 3},
  pages={786-93}
}
Methimazole [1-methyl-2-mercaptoimidazole (MMI)] was given to normal male rats in their drinking water in concentrations ranging from 0.0001-0.05% for either 1 week or 1 month. Serum MMI levels in the rats ranged from 0.008-19.6 micrograms/ml, and were similar after 1 week and 1 month of treatment. Serum MMI was linearly related to the MMI concentration in the drinking water (r = 0.98, P less than 0.001). In contrast, intrathyroid MMI content plateaued with increasing MMI concentrations in the… CONTINUE READING