Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis.

@article{Iman2003MethimazoleinducedHI,
  title={Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis.},
  author={Cağla A Işman and Berrak Cağlayan Yeğen and Inci Alican},
  journal={The Journal of endocrinology},
  year={2003},
  volume={177 3},
  pages={
          471-6
        }
}
Depression of metabolism by hypothyroidism decreases oxidant production and thus protects tIssues against oxidant damage. Moreover, it is well-known that abnormal gut motility is a common manifestation in hypo/hyperthyroidism. In this study, we aimed to investigate the putative beneficial effects of methimazole on oxidative injury and dysmotility in a rat colitis model. Methimazole (0.04%) was administered in drinking water starting 15 days prior to induction of colitis. Colitis was induced by… CONTINUE READING
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